Search on: CLAVULANIC ACIDS 
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Descriptor English:   Clavulanic Acids 
Descriptor Spanish:   Ácidos Clavulánicos 
Descriptor Portuguese:   Ácidos Clavulânicos 
Synonyms English:   Acids, Clavulanic  
Tree Number:   D02.065.589.099.374
D03.633.100.300.374
Definition English:   Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects. 
Indexing Annotation English:   /biosyn permitted if by living matter
Pharmacological Action:   Anti-Bacterial Agents
Enzyme Inhibitors
 
History Note English:   83 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   2994 
Unique Identifier:   D002969 

Occurrence in VHL:
 

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